- Deep Sequencing Transcriptome Analysis of Murine Wound Healing: Effects of a Multicomponent, Multitarget Natural Product Therapy-Tr14.
Georges St. Laurent III, Bernd Seilheimer, Michael Tackett, Jianhua Zhou, Dmitry Shtokalo, Yuri Vyatkin, Maxim Ri, Ian Toma, Dan Jones and Timothy A. McCaffrey.
Front. Mol. Biosci., 17 August 2017. - Reprogramming, Circular Reasoning and Self versus Non-self: One-Stop Shopping with RNA Editing.
Yiannis A. Savva, Ali Rezaei, Georges St. Laurent† and Robert A. Reenan.
Front. Genet., 07 June 2016. - HIV-1-exposed seronegative individuals show alteration in TLR expression and pro-inflammatory cytokine production ex vivo: An innate immune quiescence status?
Hernandez JC, St Laurent G 3rd, Urcuqui-Inchima S.
Immunol Res. 2016 Feb. - Complex interaction between dengue virus replication and expression of miRNA-133a.
Castillo JA, Castrillón JC, Diosa-Toro M, Betancur JG, St Laurent Georges III, Smit JM, Urcuqui-Inchima S.
BMC Infect Dis. 2016 Jan 27 - Genome-Wide Analysis of A-to-I RNA Editing.
Savva YA, Laurent GS, Reenan RA.
Methods Mol Biol. 2016. - The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation.
Pastori C, Kapranov P, Penas C, Peschansky V, Volmar CH, Sarkaria JN, Bregy A, Komotar R, St Laurent G, Ayad NG, Wahlestedt C.
Proc Natl Acad Sci U S A. 2015 Jul 7. - Bioregulatory systems medicine: an innovative approach to integrating the science of molecular networks, inflammation, and systems biology with the patient's autoregulatory capacity?
Goldman AW, Burmeister Y, Cesnulevicius K, Herbert M, Kane M, Lescheid D, McCaffrey T, Schultz M, Seilheimer B, Smit A, St Laurent G 3rd, Berman B.
Front Physiol. 2015 Aug 19. - The Landscape of long noncoding RNA classification
Georges St. Laurent, Claes WahlestedtEmail the author Claes Wahlestedt, Philipp KapranovEmail the author Philipp Kapranov.
Trends in Genetics; April 2015. - A vlincRNA participates in senescence maintenance by relieving H2AZ-mediated repression at the INK4 locus.
Sandra Lazorthes, Céline Vallot, Sébastien Briois, Marion Aguirrebengoa, Jean-Yves Thuret, Georges St. Laurent, Claire Rougeulle, Philipp Kapranov, Carl Mann, Didier Trouche & Estelle Nicolas.
Nature Communications; 20 January 2015. - The Evolution of Massively Parallel Sequencing Technologies: Facilitating Advances in Personalized Medicine.
Ian Toma, Georges St. Laurent III, Samuel Darko, Timothy A. McCaffrey.
August 27, 2014. Book Molecular, Cellular, and Tissue Engineering By Joseph D. Bronzino, Donald R. Peterson - SWORD: Genetic algorythm tool for protein-RNA interaction motifs recognition.
Shtokalo D., Miginsky D., Lobanov V., St Laurent III G.
Bull. Nov. Comp. Center, Comp. Science, 37 (2014), 149–162. - Dark matter RNA illuminates the puzzle of genome-wide association studies.
St Laurent G, Vyatkin Y, Kapranov P.
BMC Medicine 2014 Jun 12;12(1):97. - Identification of novel non-coding RNA-based negative feedback regulating the expression of the oncogenic transcription factor GLI1.
Villegas VE, Rahman MF, Fernandez-Barrena MG, Diao Y, Liapi E, Sonkoly E, Ståhle M, Pivarcsi A, Annaratone L, Sapino A, Ramírez Clavijo S, Bürglin TR, Shimokawa T, Ramachandran S, Kapranov P, Fernandez-Zapico ME, Zaphiropoulos PG.
Molecular Oncology 2014 Mar 22. pii: S1574-7891(14)00057-X. doi:10.1016/j.molonc.2014.03.009. [Epub ahead of print] - Proteomics Analysis of Co-Purifying Cellular Proteins Associated with rAAV Vectors.
Dong B, Duan X, Chow HY, Chen L, Lu H, Wu W, Hauck B, Wright F, Kapranov P, Xiao W.
PLoS One. 2014 Feb 3;9(2):e86453. doi: 10.1371/journal.pone.0086453. eCollection 2014. - RNA editing regulates transposon-mediated heterochromatic gene silencing
Yiannis A. Savva, James E. C. Jepson, Yao-Jen Chang, Rachel Whitaker, Brian C. Jones, Georges St Laurent, Michael R. Tackett, Philipp Kapranov, Nan Jiang, Guyu Du, Stephen L. Helfand & Robert A. Reenan
Nature Communications 4, Article number:2745 Nov (2013) - Assessing the validity and reproducibility of genome-scale predictions.
Sugden LA, Tackett MR, Savva YA, Thompson WA, Lawrence CE.
Bioinformatics. 2013 Nov 15 - On the importance of small changes in RNA expression.
St Laurent G, Shtokalo D, Tackett MR, Yang Z, Vyatkin Y, Milos PM, Seilheimer B, McCaffrey TA, Kapranov P.
Methods. 2013 Sep 1;63(1):18-24. Epub 2013 Apr 4. - Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila
Georges St Laurent, Michael R Tackett, Sergey Nechkin, Dmitry Shtokalo, Denis Antonets, Yiannis A Savva, Rachel Maloney, Philipp Kapranov, Charles E Lawrence & Robert A Reenan
Nature Structural & Molecular Biology 20, 1333–1339 Sep (2013) - A concept of eliminating nonhomologous recombination for scalable and safe AAV vector generation for human gene therapy.
Dong B, Moore AR, Dai J, Roberts S, Chu K, Kapranov P, Moss B, Xiao W.
Nucleic Acids Res. 2013 Jul;41(13):6609-17. Epub 2013 May 15. - VlincRNAs controlled by retroviral elements are a hallmark of pluripotency and cancer.
St Laurent G, Shtokalo D, Dong B, Tackett MR, Fan X, Lazorthes S, Nicolas E, Sang N, Triche TJ, McCaffrey TA, Xiao W, Kapranov P.
Genome Biol. 2013 Jul 22;14(7):R73. - Inflammation in soft tissue disorders: the evidence and potential role for a natural multi-target medication.
Wolfarth B, de Vega CG, Kapranov P, St Laurent G, Speed C.
Curr Med Res Opin. Mar 2013;29 Suppl 2:1-2. - Genomics in the assessment of a multi-component, multi-target medication in soft tissue disorders.
St Laurent G, Kapranov P.
Curr Med Res Opin. Mar 2013;29 Suppl 2:11-4 - Insights from the HuR-interacting transcriptome: ncRNAs, ubiquitin pathways, and patterns of secondary structure dependent RNA interactions.
St Laurent G 3rd, Shtokalo D, Heydarian M, Palyanov A, Babiy D, Zhou J, Kumar A, Urcuqui-Inchima S.
Mol Genet Genomics. 2012 Dec;287(11-12):867-79.Epub 2012 Oct 4. - 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary
Tarang Khare, Shraddha Pai, Karolis Koncevicius1, Mrinal Pal, Edita Kriukiene, Zita Liutkeviciute, Manuel Irimia, Peixin Jia, Carolyn Ptak, Menghang Xia, Raymond Tice, Mamoru Tochigi, Solange Moréra, Anaies Nazarians, Denise Belsham, Albert H. C. Wong, Benjamin J. Blencowe, Sun Chong Wang, Philipp Kapranov, Rafal Kustra, Viviane Labrie, Saulius Klimasauskas, and Arturas Petronis
Nat Struct Mol Biol. 2012 October ; 19(10): 1037–1043 - Intronic RNAs constitute the major fraction of the non-coding RNA in mammalian cells
Georges St Laurent, Dmitry Shtokalo, Michael R Tackett, Zhaoqing Yang, Tatyana Eremina, Claes Wahlestedt, Silvio Urcuqui-Inchima, Bernd Seilheimer, Timothy A McCaffrey and Philipp Kapranov
BMC Genomics 2012, Sep 13 - Regulation of chromatin structure by long noncoding RNAs: focus on natural antisense transcripts
Magistri M, Faghihi MA, St Laurent G 3rd, Wahlestedt C
Trends Genet. 2012 Aug;28(8):389-96. Epub 2012 Apr 26. - The Emerging Role of Non-Coding RNAs in Drug Addiction
Sartor GC, St Laurent G 3rd, Wahlestedt C.
Front Genet. 2012 Jun 22;3:106. - Genomic “Dark Matter”: Implications for Understanding Human Disease Mechanisms, Diagnostics, and Cures
Philipp Kapranov and Georges St. Laurent
Front Genet. 2012; 3: 95. 2012 May 29 - Dark matter RNA: an intelligent scaffold for the dynamic regulation of the nuclear information landscape.
St Laurent G, Savva YA, Kapranov P.
Front Genet. 2012 Apr 26;3:57. - Dark Matter RNA: Existence, Function, and Controversy.
Kapranov P, St Laurent G
Front Genet. 2012 Apr 23;3:60. - Toward knowing the whole human: next-generation sequencing for personalized medicine
Ian Toma1, Georges St Laurent & Timothy A McCaffrey
Personalized Medicine, July 2011, Vol. 8, No. 4, Pages 483-491 - The majority of total nuclear-encoded non-ribosomal RNA in a human cell is ‘dark matter’un-annotated RNA
Philipp Kapranov, Georges St Laurent, Tal Raz, Fatih Ozsolak, C Patrick Reynolds, Poul HB Sorensen, Gregory Reaman, Patrice Milos, Robert J Arceci, John F Thompson, Timothy J Triche, Kapranov et al.
BMC Biology 2010, 8:149 - RNAi screen indicates widespread biological function for human natural antisense transcripts.
Faghihi MA, Kocerha J, Modarresi F, Engström PG, Chalk AM, Brothers SP, Koesema E, St Laurent G, Wahlestedt C.
PLoS One. 2010 Oct 4;5(10). - Primary hepatocyte culture supports hepatitis C virus replication: a model for infection-associated hepatocarcinogenesis.
Banaudha K, Orenstein JM, Korolnek T, St Laurent GC 3rd, Wakita T, Kumar A
Hepatology. 2010 Jun;51(6):1922-32 - Evidence for natural antisense transcript-mediated inhibition of microRNA function.
Faghihi MA, Zhang M, Huang J, Modarresi F, Van der Brug MP, Nalls MA, Cookson MR, St-Laurent G 3rd, Wahlestedt C.
Genome Biol. 2010;11(5):R56Epub 2010 May 27. - A LINE-1 component to human aging: do LINE elements exact a longevity cost for evolutionary advantage?
St Laurent G 3rd, Hammell N, McCaffrey TA.
Mech Ageing Dev. 2010 May;131(5):299-305.Epub 2010 Mar 25 - Modified PSWM for RNA editing sites search
Shtokalo D, Nechkin S, Eremina T, Cheremushkin E, St. Laurent G
Bioinformatics of Genome Regulation and Structure (BGRS), 2010 - Propagation of kinetic uncertainties through a canonical topology of the TLR4 signaling network in different regions of biochemical reaction space
Jayson Gutiérrez, Georges St Laurent III, Silvio Urcuqui-Inchima
Theoretical Biology and Medical Modelling March 2010 - Enhancing non-coding RNA information content with ADAR editing.
St Laurent G 3rd, Savva YA, Reenan R.
Neurosci Lett. 2009 Dec 4;466(2):89-98. Epub 2009 Sep 12. - Non-coding RNA transcripts: sensors of neuronal stress, modulators of synaptic plasticity, and agents of change in the onset of Alzheimer's disease.
St Laurent G 3rd, Faghihi MA, Wahlestedt C.
Neurosci Lett. 2009 Dec 4;466(2):81-8 Epub 2009 Aug 20. - Cardiovascular inflammation and lesion cell apoptosis: a novel connection via the interferon-inducible immunoproteasome.
Yang Z, Gagarin D, St Laurent G 3rd, Hammell N, Toma I, Hu CA, Iwasa A, McCaffrey TA.
Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1213-9. Epub 2009 May 14. - The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line.
FANTOM Consortium, Suzuki H, Forrest AR, van Nimwegen E, Daub CO, Balwierz PJ, Irvine KM, Lassmann T, Ravasi T, Hasegawa Y, de Hoon MJ, Katayama S, Schroder K, Carninci P, Tomaru Y, Kanamori-Katayama M, Kubosaki A, Akalin A, Ando Y, Arner E, Asada M, Asahara H, Bailey T, Bajic VB, Bauer D, Beckhouse AG, Bertin N, Björkegren J, Brombacher F, Bulger E, Chalk AM, Chiba J, Cloonan N, Dawe A, Dostie J, Engström PG, Essack M, Faulkner GJ, Fink JL, Fredman D, Fujimori K, Furuno M, Gojobori T, Gough J, Grimmond SM, Gustafsson M, Hashimoto M, Hashimoto T, Hatakeyama M, Heinzel S, Hide W, Hofmann O, Hörnquist M, Huminiecki L, Ikeo K, Imamoto N, Inoue S, Inoue Y, Ishihara R, Iwayanagi T, Jacobsen A, Kaur M, Kawaji H, Kerr MC, Kimura R, Kimura S, Kimura Y, Kitano H, Koga H, Kojima T, Kondo S, Konno T, Krogh A, Kruger A, Kumar A, Lenhard B, Lennartsson A, Lindow M, Lizio M, Macpherson C, Maeda N, Maher CA, Maqungo M, Mar J, Matigian NA, Matsuda H, Mattick JS, Meier S, Miyamoto S, Miyamoto-Sato E, Nakabayashi K, Nakachi Y, Nakano M, Nygaard S, Okayama T, Okazaki Y, Okuda-Yabukami H, Orlando V, Otomo J, Pachkov M, Petrovsky N, Plessy C, Quackenbush J, Radovanovic A, Rehli M, Saito R, Sandelin A, Schmeier S, Schönbach C, Schwartz AS, Semple CA, Sera M, Severin J, Shirahige K, Simons C, St Laurent G, Suzuki M, Suzuki T, Sweet MJ, Taft RJ, Takeda S, Takenaka Y, Tan K, Taylor MS, Teasdale RD, Tegnér J, Teichmann S, Valen E, Wahlestedt C, Waki K, Waterhouse A, Wells CA, Winther O, Wu L, Yamaguchi K, Yanagawa H, Yasuda J, Zavolan M, Hume DA; Riken Omics Science Center, Arakawa T, Fukuda S, Imamura K, Kai C, Kaiho A, Kawashima T, Kawazu C, Kitazume Y, Kojima M, Miura H, Murakami K, Murata M, Ninomiya N, Nishiyori H, Noma S, Ogawa C, Sano T, Simon C, Tagami M, Takahashi Y, Kawai J, Hayashizaki Y.
Nat Genet. 2009 May;41(5):553-62.Epub 2009 Apr 19. - Molecular mechanism underlying differential apoptosis between human melanoma cell lines UACC903 and UACC903(+6) revealed by mitochondria-focused cDNA microarrays.
Zhang Q, Wu J, Nguyen A, Wang BD, He P, Laurent GS, Rennert OM, Su YA.
Apoptosis. 2008 Aug;13(8):993-1004. - Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase.
Faghihi MA, Modarresi F, Khalil AM, Wood DE, Sahagan BG, Morgan TE, Finch CE, St Laurent G 3rd, Kenny PJ, Wahlestedt C.
Nat Med. 2008 Jul;14(7):723-30Epub 2008 Jun 29. - Noncoding RNAs: couplers of analog and digital information in nervous system function?
St Laurent G 3rd, Wahlestedt C.
Trends Neurosci. 2007 Dec;30(12):612-21. Epub 2007 Nov 8. - Meta-analysis of microarray results: challenges, opportunities, and recommendations for standardization.
Cahan P, Rovegno F, Mooney D, Newman JC, St Laurent G 3rd, McCaffrey TA.
Gene. 2007 Oct 15;401(1-2):12-8. Epub 2007 Jul 3. - Nuclear Factor 90(NF90) targeted to TAR RNA inhibits transcriptional activation of HIV-1.
Agbottah ET, Traviss C, McArdle J, Karki S, St Laurent GC 3rd, Kumar A.
Retrovirology. 2007 Jun 12;4:41. - Nuclear Factor 90, a cellular dsRNA binding protein inhibits the HIV Rev-export function.
Urcuqui-Inchima S, Castaño ME, Hernandez-Verdun D, St-Laurent G 3rd, Kumar A.
Retrovirology. 2006 Nov 24;3:83. - Biodegradation of low aqueous concentration pentachlorophenol (PCP) contaminated groundwater.
Schmidt LM, Delfino JJ, Preston JF 3rd, St Laurent G 3rd.
Chemosphere. 1999 May;38(12):2897-912. - Lactoferrin biosynthesis during granulocytopoiesis.
Rado TA, Bollekens J, St Laurent G, Parker L, Benz EJ Jr.
Blood. 1984 Nov;64(5):1103-9. - Interferon action: two (2'-5')(A)n synthetases specified by distinct mRNAs in Ehrlich ascites tumor cells treated with interferon.
St Laurent G, Yoshie O, Floyd-Smith G, Samanta H, Sehgal PB, Lengyel P.
Cell. 1983 May;33(1):95-102.
